Minecraft wins by a landslide! It was also a contender for Best Game About Nothing, but you could argue that it's less a game and more a litmus test for autism. The test would go something like this:
Have you ever stayed up all night mining stone blocks for the scaffolding on your life size Arc de Triomphe? Check one of the following.
It's easy to laugh at these people, but imagine someone gives you an infinite box of legos and tells you to just go nuts. Yeah...I would lose my job for sure. Anyway Minecraft is an incredible feat in that it was developed by one guy and funded almost entirely by pre-orders. Did I mention it's also incredibly fun and addicting to anyone with even the smallest ounce of creativity?